Synergic effect of quinolone antibacterial agents and proton pump inhibitors on Helicobacter pylori
نویسندگان
چکیده
منابع مشابه
Synergic effect of quinolone antibacterial agents and proton pump inhibitors on Helicobacter pylori.
1New Product Research Laboratories I, Daiichi Pharmaceutical Co. Ltd, 16-13 Kitakasai 1-Chome, Edogawa-ku, Tokyo 134-8630; 2Department of Preventive Dentistry, Health Sciences University of Hokkaido; 3Division of Animal Experimentation, Sapporo Medical University, Hokkaido; 4Department of Microbiology, Jichi Medical University, Tochigi; 5Hokkaido Institute of Technology and 6Third Department of...
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Proton pump inhibitors have become of pivotal importance for the treatment of GERD. The purpose of this paper is to review the interaction between Helicobacter pylori and PPIs in the treatment of GERD. H. pylori exaggerates the acid suppressive effects of PPIs. During treatment with these drugs, H. pylori-positive subjects thus have a higher intragastric pH than H. pylori-negative subjects. The...
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The bactericidal activity of the proton pump inhibitors omeprazole and lansoprazole alone and in combination with a beta-lactam or macrolide antibiotic were investigated in vitro. Time-kill curves against Helicobacter pylori NCTC 11637 and a recent clinical isolate revealed significant concentration-dependent killing with all drugs other than amoxycillin. Combinations of proton pump inhibitor a...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2002
ISSN: 1460-2091
DOI: 10.1093/jac/dkf055